Benchenane Karim, PhD
Work experience since graduation
Currently: Full permanent CNRS Researcher (CR1)
MOBs team, Laboratory of Neurobiology - UMR 7637 CNRS ESPCI
Research focus: Brain states, oscillation and memory processes
Post-doctoral scholar at the CMBN, Rutgers University, Newark, USA. (2005) PI: Esther Nimchinsky
Research focus: Study of the role of astrocytes in neuronal plasticity with two-photon microscopy.
PhD in Molecular and Cellular Neuroscience in UMR 6551, University de Caen - CNRS, Caen, France.
Award date Dec, 21th 2004. PhD advisors Pr Denis Vivien and Dr Omar Touzani.
Research focus: Interaction between the tissue-type plasminogen activator and the NMDA receptor: involvement in ischemic neuronal death and in learning and memory.
• Bachelor, Master in Biology (2000)
• Bachelor in Psychology (2000)
• Preparatory classes for competitive exams to enter french 'Grandes Ecoles' (Mathematics & Physics)
Supervision of students • Sophie Bagur (ENS student) • Gaetan de la Villéon (PhD currently) • Marie Lacroix (PhD currently) • Matthieu Tihy (Master, 2011)
• Lisa Roux (PhD, principal advisor: Christian Giaume, 2010-2011)
• 2010: Funding Neurosciences and Computational Neuroinformatic, Neuro-IC (35 000 €).
Principal investigator of the Project: MMN-P3B: A cortical column model to account for the mismatch negativity in the auditory pathway (in collaboration with Dr Stanislas Dehaene and Dr Alain Destexhe).
• PhD fellowship from the French ministry of Research
Awards and prizes
• Award “Prix la Recherche” (2011):
Best article in Neuroscience for 2010 delivered by the journal La Recherche, for the study Benchenane K, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia FP, Wiener SI. (2010) Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Neuron, June 24;66(6):921-36.
• Award AXA–French Academy of Science (2010):
“Major advances in biological studies in France presented by the authors” for the article: Girardeau G*, Benchenane K*, Wiener SI, Buzsáki G, Zugaro MB. (2010) "Selective suppression of hippocampal ripples perturbes learning in a spatial reference memory task". Nat. Neurosci, Oct;12(10):1222-23. (*equal contribution)
Lecturer in 1st and 2nd year of Master in University Pierre and Marie Curie (2010 -2012)
Lecturer in 2nd year of Master in University Paris-Sud (2012).
Lecturer in Engineer school ESPCI-Paris Tech, Paris, France. (2012)
Participation to the organization of the 5th national forum of cognitive science (2006)
Valorization and patent
During my PhD, I have shown that a protocol of vaccination that leads to the generation of antibodies that prevent the cleavage of the NMDA receptor by the tissue-type plasminogen activator prevent the deleterious effect of tPA in the brain parenchyma while leaving its beneficial proteolytic action in the blood unaffected (Benchenane et al., J Cell Sci 2007).
This strategy is currently in pre-clinical test, and a patent has been done in collaboration with a pharmaceutical company (Paion) in order to perform a clinical trial with the co-administration of tPA and the antibody.
Patent EP2289542; EUROPEAN PATENT APPLICATION, EP 2 289 542 A1, Treatment of neurological or neurodegenerative disorders. Application number: 09011149.3
Other academic activities
Reviewer for Brain Research, Neuroscience, PLOS One. Circulation, Stroke.
• Member of the Scientific Council of the French Research Group on Sleep • Member of the Research Group on Neuroscience of memory (NeuroMem) GDR 2905
• Member of the Research Group on multiple-electrode recording (Multi- electrode Systems and Signal Processing for Neural Networks) GDR 2904
Collaborators (classified by alphabetical order)
Angelo Arleo, Université Pierre et Marie Curie, Paris, France
Thierry Bal, CNRS, Gif sur Yvette, France
Francesco P. Battaglia, Amsterdam University, Amsterdam, The Netherlands
Gyorgy Buzsaki, Rutgers University, Newark, USA
Stanislas Dehaene, INSERM, CEA, Collège de France, Paris, France
Alain Destexhe, CNRS, Gif sur Yvette, France
Christian Giaume, INSERM, Collège de France, Paris, France
Yves Gioanni, Collège de France, Paris, France
Benoît Girard, Université Pierre et Marie Curie, Paris, France
Mark Humphreys, Sheffield University, Sheffield, United Kingdom
Adrien Peyrache, Rutgers University, Newark, USA
Emmanuel Procyk, INSERM, Stem cells and Brain Research Institute, Bron, France
Nathalie Rouach, INSERM, Collège de France, Paris, France
Denis Vivien, INSERM Université de Caen, Caen, France
- My Neurotree page
- My Academia page